After decades of individual attempts to identify the structure of the main building block of HDL (high-density lipoproteins), the so-called “good” cholesterol that associates with protection from cardiovascular disease, a research team representing eight academic institutions across the U.S. and Australia has come to agreement on a predictive model.
Their study, “A Consensus Model of Human Apolipoprotein A-I in its Monomeric and Lipid-Free State” is currently available online in the journal Nature Structure and Molecular Biology.
“We are excited to finally have a robust picture of what this protein looks like,” says Sean Davidson, PhD, professor and vice chair in the Department of Pathology and Laboratory Medicine at the University of Cincinnati (UC) College of Medicine, and the corresponding author on the study.
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